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St. Luke's may refer to:

St Luke's, Islington, a district of London, UK
St Luke's, Old Street, church of the above parish
St. Luke's Campus, part of the University of Exeter, Exeter, Devon, England
St Luke's railway station, Southport, Merseyside, UK
St. Luke's Health Network, a hospital/health network in Bethlehem, Pennsylvania, USA
Saint Luke's Health System, a health care system and affiliated hospitals around Kansas City, Missouri, USA
Saint Luke's Home for Destitute and Aged Women in Middletown, Connecticut, USA
St. Luke's School (disambiguation)
St. Luke's Church (disambiguation)
St Luke's Hospital (disambiguation)
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